Macrophages and monocytes are amongst the cells of the immune system affected by alcohol consumption that contribute to RA disease progression by secreting pro-inflammatory cytokines such as TNF-α, IL-6, GM-CSF, IL-15, IFN-α/β, VEGF, FGF, CC, and CXC chemokines, ultimately fueling synovial destruction [12]. This evidence concerns the gene TNF and rheumatoid arthritis.