Moreover, CTLA-4 blockade enhanced the infiltration of eosinophils (CD45+, CD11b+, CD11c−, Ly6G−, SSChi) into tumors, regardless of CD80 expression on tumor cells, and increased the frequency of MHC-II− M2 macrophages within the subpopulation of TAMs in TC-1-induced tumors. This evidence concerns the gene CTLA4 and neoplasm.