Several lines of evidence disclose the involvement of HO-1 as cytoprotective defense in the pathogenesis of various neurodegenerative diseases, including Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), and Parkinson’s disease (PD) [122,123,124,125,126,127]. Here, HMOX1 is linked to amyotrophic lateral sclerosis.