HO-1, also known as Heat shock protein 32 (Hsp32), is the inducible isoform whose expression can be upregulated by different stress conditions and activated by multiple stimuli, including UV irradiation, infections, heavy metals, nitric oxide, cytokines, and oxidized Low-Density Lipoprotein (LDL) [4]; HO-2 and HO-3 represent the constitutive isoforms expressed at basal levels in most of human tissues, in particular there are higher concentration levels of this isoforms in neurons, the spleen, and the liver [5]. The gene discussed is HMOX1; the disease is infection.