The results showed that both COL4A3 and ZEB1 were expressed in normal human corneal endothelial cells, although in PPCD3, the expression of ZEB1 was reduced compared to the levels of the gene in the healthy control cornea where the expression of COL4A3 was increased, indicating that ZEB1-mediated changes in COL4A3 expression are most likely related to the pathogenesis of the corneal endothelial dystrophy [43]. Here, ZEB1 is linked to corneal endothelial dystrophy.