Furthermore, they used transcriptomics methods to validate the ZEB1 monoallelic knockout cell line as a cell-based model of PPCD, a new mesenchymal to epithelial transition (MET)-like process called endothelial-to-epithelial transformation (EnET), and proposed the inference of the MET paradigm that explains the PPCD phenotype and the pathogenesis of PPCD [42]. This evidence concerns the gene ZEB1 and posterior polymorphous corneal dystrophy.