To investigate the effects of IFN-γ on EHV-1 infection in human cells, lung fibroblasts MRC-5, lung epithelial A549, and melanoma MeWo cells were treated with 0 or 20 ng of human IFN-γ and infected with EHV-1 KyA or RacL11 at 24 h post-treatment. This evidence concerns the gene IFNG and melanoma.