TP53 and neoplasm: Among these, highly prevalent chromosomal deletions have been described in tumor suppressor genes, such as TP53, ZEB1, RB1, PTEN, DNMT3A, and CDKN1B. Interestingly, the ratio of TP53 deletions to mutations is significantly higher in MF/SS than in other tumors (5.1 vs. 1) [27].