Providing further evidence of their involvement in CTCL, highly recurrent genetic alterations (SNVs and copy number variants) have been detected in JAK/STAT genes in ≥60% of the MF/SS cases analyzed [25,27,32,35,36,37,38,40,41,43]. The gene discussed is SOAT1; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.