Recent kinome profiling of PEL cell lines using kinase inhibitor-conjugated beads to capture kinases followed by quantitative MS revealed Tyro3 as a potential therapeutic target with subsequent analyses revealing that Tyro3 inhibition reduced PEL survival and growth in vitro, and tumor burden in a mouse PEL xenograft model in vivo [321]. The gene discussed is TYRO3; the disease is neoplasm.