PIK3CG and primary effusion lymphoma: Activation of PIK3/AKT signaling and STAT3 via constitutive phosphorylation contribute to the growth and survival of primary effusion lymphoma (PEL) cells, a type of NHL driven by dual infection with Epstein Barr virus (EPV) and Kaposi sarcoma–associated herpesvirus (KSHV) [317,318].