PTM analysis in MM has revealed aberrant modifications of major proteins involved in signaling pathways known to play a role in MM carcinogenesis and progression, such as JAK/STAT signaling, PI3K/Akt/mammalian target of rapamycin (mTOR) and Ras/Raf/MEK/Erk. This evidence concerns the gene MAP2K7 and Miyoshi myopathy.