IKZF1 and Miyoshi myopathy: Lenalidomide targets Cereblon, the substrate recognition subunit of a biologically important Cullin RING E3 ubiquitin ligase complex, resulting in the degradation of two B-cell transcription factors, Ikaros (IKZF1) and Aiolos (IKZF3), that are essential for the survival of MM cells [207].