APP and Alzheimer disease: In sum, (i) both brain tissue and AT have elevated APP levels in obese patients, (ii) there is extraneuronal production of both APPs and Aβ peptides, including in AT, and (iii) the administration of streptozotocin, a well-known experimental model for type 1 diabetes, induces brain insulin resistance and cognitive alterations resembling the status of AD patients [47].