GDF11 and Alzheimer disease: Since then, GDF11 has been heralded as a “fountain of youth” with several studies showing that systemic supplementation of GDF11 levels rejuvenates heart and skeletal muscle tissue in aged mice, reduces atherosclerotic lesion formation, rescues cognitive and cerebrovascular function and ameliorates Aβ levels in mice used to model AD [58,59,60,61].