The identified DEGs were expressively assigned to ‘anatomical structure development’, ‘neuron differentiation‘, ‘leukocyte migration’, ‘immune response’ and ‘primary immunodeficiency’, etc. Leukocyte migration as a part of immune reactions was displayed by downregulated genes (IL1B, RET, CCL8, THY1, LCK, WNT5A, CYP7B1, CXCR4, CD44). The gene discussed is IL1B; the disease is inborn error of immunity.