It has been noted that TLR polymorphisms such as TLR1 (rs5743571 and rs5743604), TLR6 (rs5743794) and TLR10 (rs11466617) and genetic variants TLR2 mutations may increase the susceptibility to AD by increasing colonization with Staphylococcus aureus [45,46]. The gene discussed is TLR2; the disease is Alzheimer disease.