TARDBP and amyotrophic lateral sclerosis: In particular, acetylated TDP-43 at Lys145 could be detected in lesions in ALS but not FTD patients, suggesting that TDP-43 acetylation was linked to ALS pathogenesis and could be used for discriminating ALS from FTD, which is helpful as a biomarker if easily detectable in body fluids [29].