However, in the CSF, it has been shown that TDP-43 concentration is higher in ALS patients (6.92 ± 3.71 ng/mL) than in healthy subjects (5.31 ± 0.94 ng/mL) and people affected by other conditions, for example, PD, multiple sclerosis, and Guillain-Barré syndrome [73]. Here, TARDBP is linked to amyotrophic lateral sclerosis.