BACE1 and memory impairment: In a model of diabetes-induced memory impairment, it has been observed the upregulation of the expression levels of miR-146a, miR-9, TNF-α, NF–kB, and subsequently amyloid-β protein precursor (AβPP), beta-site APP cleaving enzyme 1 (BACE1), and BCL2 associated X, apoptosis regulator (Bax) [104].