The APRI score was higher in Pi*ZZ patients than in heterozygous Z (0.35 (SD: 0.18) vs. 0.27 (SD: 0.09); p = 0.007), but most of the patients had APRI values < 0.5, excluding advanced fibrosis or cirrhosis, and only one Pi*ZZ patient had an APRI score > 1.0. The gene discussed is SERPINA1; the disease is Cirrhosis.