A meta-analysis of 16 studies estimated that the pooled sensitivity and specificity of anti-MDA5 antibodies for RP-ILD were 77% (95% confidence interval (CI), 64%–87%) and 86% (95% CI, 79%–90%), respectively, with a pooled diagnostic odds ratio of 20.41 (95% CI, 9.02–46.20) [16]. Here, IFIH1 is linked to interstitial lung disease.