Recently, several myositis-specific autoantibodies not detected in patients with inherited muscle diseases have been identified [2], and they include anti-transcriptional intermediary factor 1 (TIF1) γ, anti-nuclear matrix protein 2 (NXP2), anti-melanoma differentiation-associated protein 5 (MDA5), anti-Mi-2, and anti-small ubiquitin-like modifier activating enzyme (SAE) antibodies, in addition to already established anti-aminoacyl-transfer RNA synthetase (ARS) antibodies, including anti-Jo-1 antibody. The gene discussed is IFIH1; the disease is myositis disease.