SLC6A4 and Stroke: Although the functional role of 5-HTT methylation remains highly speculative, our findings support a role for SLC6A4 promoter methylation in stroke recovery; an implication of this results to verify in further studies could be the use of 5-HTT methylation as prognostic biomarker for long-term rehabilitation, and in conjunction with 5-HTTLPR polymorphism for favorable and unfavorable outcomes.