In ChREBP knockdown fructose-fed rats, a low level of circulating triglycerides was demonstrated, confirming the role of ChREBP in fructose-mediated dyslipidemia but not on steatosis development, highlighting that fat accretion in lipid droplets and very low-density lipoprotein (VLDL) secretion are distinct processes [56]. Here, MLXIPL is linked to metabolic syndrome.