We have long been interested in discovering naturally occurring small molecules that inactivate nuclear NR4A1 in the treatment of cancers that overexpress this orphan receptor, and we recently isolated and identified FCN, a bisbenzyltetrahydroisoquinoline alkaloid from Stephania tetrandra, as the first natural inactivator of nuclear NR4A1 that induces apoptosis in pancreatic cancer cells partly via nuclear NR4A1-dependent pro-apoptotic pathways as mentioned above [7]. The gene discussed is NR4A1; the disease is familial pancreatic carcinoma.