For this reason, the aim of this article was to evaluate the diagnostic suitability of the serum profile of extracellular matrix components such as sulfated glycosaminoglycans (sGAG), hyaluronan (HA), and soluble syndecan-1 (sCD138) fragments in patients with inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. The gene discussed is SDC1; the disease is ulcerative colitis.