For example, the antagonist of β1-adrenergic receptors, nebivolol, decreases vascular MMP-2 activity and attenuates hypertension-induced vascular remodeling and collagen deposition by mechanisms apparently independent of β1 adrenoceptor-blocking properties, probably related to diminished NADPH oxidase activity decreasing ROS formation [103,106]. The gene discussed is MMP2; the disease is Hypertension.