SMAD2 and Familial prostate cancer: TQ (10 μM) inhibited the migration metastasis of prostate cancer by reducing the expression of epithelial–mesenchymal transition (EMT) markers in DU145 and PC3 prostate cancer cell lines and reduced transforming growth factor beta (TGF-β), Smad2, and Smad3, which are essential intracellular signaling components [85].