There are several syndromes (mutated genes) associated with the patent DA, such as Cantú (ABCC9), Char (TFAP2B), DiGeorge (TBX1), Holt-Oram (TBX5), and Rubinstein–Taybi (CREBBP) syndromes [52,53,54]. The gene discussed is TBX5; the disease is Down syndrome.