RFE identified 14 pre-treatment variables as the most relevant predictors of mortality in TAVI patient at 5-years follow-up: MR etiology, stroke volume index, interventricular septal thickness, left atrium area, aortic valve area, mean aortic pressure gradient, creatinine, alanine aminotransferase, hemoglobin, international normalized ratio, age, spironolactone, angina, and EuroSCORE II (Table 3). The gene discussed is GPT; the disease is angina pectoris.