We could summarize that a good candidate to restore HCC-specific CD8 T cell response by PD-1/PD-L1 blockade could be considered those tumors with high grade of IFN-γ-secreting TIL, high PD-L1 expression, low M2 macrophage infiltration, and presence of HCC neo-antigens. This evidence concerns the gene CD274 and hepatocellular carcinoma.