CCNG2 and glioblastoma: Moreover, hypoxia controls cytoskeletal dynamics to promote local invasion through actin cytoskeleton remodeling, as reported by Fujimura and colleagues, who identified Cyclin G2 (upregulated in 2898-gene signature with a high fold change value of 5.49), as a driver gene in promoting local invasion, by cytoskeletal remodeling under hypoxia in GBM [57].