hTSC1 had little effect on the proliferation of Ast #2 + hTSC1 tumor cells, while Rapamycin treatment reduced the Ki67+ cells in these tumors (6.5 ± 2.3% with Rapamycin vs. 22.8 ± 3.5% with Vehicle, p < 0.01) (Figure 6E). Here, MKI67 is linked to neoplasm.