L-SIL lesions display a nuclear and cytoplasmic positivity for p16 limited to the lower third of squamous epithelium; however, different staining patterns have been reported according to HPV type of infection: Intermediate and high-risk HPV-related L-SIL usually display strong and continuous p16 expression while low risk HPV-related L-SIL exhibits a less specific weak or focal p16 staining [3,5,13,14,15,16]. Here, CDKN2A is linked to squamous cell intraepithelial neoplasia.