In conclusion, based on an alternative bioinformatic approach applied to RNA-Seq data, we selected candidate molecules that could be involved in a post-transcriptional mechanism of RNA competition, and we provided data suggesting a novel RNA network composed by lncRNAs, miRNAs, and mRNAs, which is affected by the dual PI3K/mTOR pharmacological inhibition in DLBCL cell lines. Here, MTOR is linked to diffuse large B-cell lymphoma.