PLAUR and glioblastoma: Antisense RNA technology has been first suggested by Go et al., which showed that human glioblastoma cells transfected with a construct corresponding to 300 bp of the human uPAR 5’ end in an antisense orientation, failed to invade fetal rat brain aggregates in vitro; further, stable transfectants, negative for uPAR expression, injected intracerebrally, failed to form tumors in nude mice [151].