High uPAR expression on cancer cells and/or elevated levels of suPAR correlate with poor prognosis; in some cases, for instance in acute myeloid leukemia, multiple myeloma, breast and ovary cancer, elevated uPAR level is associated also with resistance to chemotherapy, and, in papillary thyroid carcinoma, with reduced patient disease-free interval [57]. The gene discussed is PLAUR; the disease is AL amyloidosis.