Hypoxia, that frequently occurs during cancer progression, induces EMT and increases uPAR expression; uPAR silencing in breast cancer, medulloblastoma and nasopharyngeal carcinoma cells inhibits hypoxia-induced EMT, whereas uPAR over-expression mimics EMT in normoxia [63,64,65]. This evidence concerns the gene PLAUR and nasopharyngeal carcinoma.