MSCs from myeloma patients (MM-MSCs) interrelate with MM cells and change the expression of certain angiogenic and growth factors (such as CD40/40L, VCAM-1, ICAM-1, LFA-3 and HO-1) and several cytokines (IL-6, IL-10 TGFb1, macrophage inflammatory protein-1b (MIP-1b) and IL-7) [68,69,70,71,72,73]. Here, IL6 is linked to plasma cell myeloma.