A number of cytokines such as IL-6, B-cell-activating factor (BAFF), a proliferation inducing ligand (APRIL), as well as other factors such as Receptor Activator of NF-κB (RANK), Vascular Endothelial Growth factor (VEGF), Colony stimulating factor-1 (CSF1), Fibroblast Growth factor-2 (FGF-2), angiopoietin-1, and IL-8 can boost the proliferation, survival, migration and drug resistance of MM cells [48,49]. This evidence concerns the gene TNFSF13 and Miyoshi myopathy.