Given β2GPI is the major antigen for autoantibodies that highly involve in the APS, we therefore treated BMDCs and T cells with 50 μg/mL of β2GPI under the same conditions as previous LPS treatments and measured the co-stimulatory molecule expressions as well as the cytokine productions from BMDCs and T cells. This evidence concerns the gene APOH and autoimmune polyendocrinopathy.