Mediators of tumor-associated immune suppression include, but are not limited to, the recruitment of immunosuppressive cells (e.g., MDSC, Treg), the expression of immune checkpoint proteins, production of TGF-β [129] or CCL21 [130], and induction of cell death in anti-tumor effector cells [2,131]. This evidence concerns the gene TGFB1 and neoplasm.