TGFB1 and neoplasm: Importantly, initiation of TGFβ neutralizing antibody treatment (24 h post inoculation) occurred after tumor dissemination to bone had already occurred and stabilized (e.g., 34.2 ± 7.5 vs. 36.7 ± 6.0 43-4M tumor cells per 106 marrow cells, respectively, were detected in hind limbs 24 vs. 72 h post inoculation in vehicle-treated mice (p > 0.05, n = 4/group)).