SLC25A4 and autosomal dominant progressive external ophthalmoplegia: In conclusion, although the specific molecular mechanism of action of the selected drugs (otilonium bromide, benzydamine HCl, pergolide mesylate, trifluoperazine 2HCl, and sertraline HCl) is not yet identified and requires further investigation, the identification of molecules able to rescue both OXPHOS defect and mtDNA instability could be a starting point for the development of pharmacological therapies for the treatment of adPEO disorder due to ANT1 mutations.