MRC1 and neoplasm: Following their infiltration into solid tumours, tumour-derived cytokines such as IL-4 and IL-10 can polarise these macrophages into a so-called M2-like phenotype (F4/80+ CD206+ CD11c-), giving rise to TAMs that are immunosuppressive (compared to its immunostimulatory M1-like phenotype counterpart (F4/80+ CD206- CD11c+)).