HIF1A and hepatocellular carcinoma: Knockdown of HIF-1α in murine hepatocellular carcinomas (Hep3B, HepG2 and SK-Hep-1 cell lines) led to reduced HIF-1-mediated upregulation of CCL28 expression, which can potentially lead to reduced Treg recruitment and Treg-induced tumour angiogenesis [93].