PNPLA3 (the Patatin-like phospholipase domain containing 3) gene is involved in the LD (lipid droplets) metabolism and VLDL (very-low-density lipoprotein) secretion; this gene’s SNP site was linked with NAFLD and studied by many researchers around the globe. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.