In our study, a panel of 17 proteins (APRIL/TNFSF13, sCD30/TNFRSF8, IFN-α2, IFN-γ, IL-2, sIL-6Rα, IL-8, IL-11, IL-29/IFN-λ1, LIGHT/TNFSF14, MMP-1, MMP-2, MMP-3, osteocalcin, osteopontin, TSLP, and TWEAK/TNFSF12) was selected by means of cross-validation to be sufficiently informative of the comparison between the TB versus LTBI children. This evidence concerns the gene SPP1 and tuberculosis.