On the other hand, the expression of MMP-2, as well as MMP-1, -3, -9, -12, -13, and -14 was found to be up-regulated in the lungs of TB-infected rabbits with destructive pathology, and a recent microarray study carried out on a macaque model showed significantly elevated levels of MMP-1, -2, -7, -9, and -14 four weeks after M.tb infection [41,42]. This evidence concerns the gene MMP1 and tuberculosis.