In parallel, in the 5-fold cross-validation analysis between the HC versus LTBI groups, we identified the panel of 15 proteins (IL-6, APRIL/TNFSF13, sCD30/TNFRSF8, gp130/sIL-6β, IL-2, sIL-6Rα, IL-8, IL-29/IFNλ1, IL-35, MMP-2, MMP-3, OPN, PTX-3, sTNF-R2, TWEAK/TNFSF12), while between the HC versus TB groups, 16 proteins (APRIL/TNFSF13, sCD30/TNFRSF8, chitinase 3-like 1, sIL-6Rα, IL-8, IL-11, IL-12(p70), IL-19, IL-28A/IFN-λ2, LIGHT/TNFSF14, MMP-1, MMP-2, MMP-3, OPN, PTX-3, TWEAK/TNFSF12) with the best discriminating potential (Table 4). This evidence concerns the gene TNFRSF8 and tuberculosis.