APC and polyposis: Furthermore, the loss of the APC gene, which is mutated in polyposis patients and in the majority of sporadic human CRCs, activates gp130-mediated IL-6 signaling, which induces STAT3 activation and, in turn, the activation of target genes involved in the neoplastic transformation of colon and rectal mucosa, such as Src family kinases (SFKs), YAP, and Notch [82].