Adenomatous polyposis syndromes include familial adenomatous polyposis (FAP), attenuated FAP (AFAP), and MUTYH-associated polyposis (MAP); hamartomatous polyposis syndromes consist of PTEN hamartoma tumor syndrome (PHTS), juvenile polyposis syndrome (JPS), and Peutz–Jeghers syndrome (PJS). This evidence concerns the gene FAP and PTEN hamartoma tumor syndrome.