PTEN and PTEN hamartoma tumor syndrome: In agreement with this hypothesis, we previously demonstrated cytokine pathway dysregulation in patients with manifestations of the “PTEN hamartoma tumor syndrome”, suggesting that the dysregulation of the PTEN pathway could promote, in non-neoplastic cells from the blood and colon tissues of PHTS patients, cell survival and pro-inflammatory stimulation, which could predispose these patients to the development of multiple cancers [85].