STAT3 and colorectal carcinoma: In agreement with this observation, the loss of APC, which is a gene considered to be a gatekeeper of intestinal epithelial turnover, has been described to be associated with the upregulation of IL-6 signaling, which, in turn, activates families of proteins that are often upregulated in CRC, such as the Src family kinases (SFKs), YAP, and STAT3 [19].