Preclinical studies suggested that onion bulbs and its active components may be considered as prophylactic or therapeutic agents against diabetes through a variety of mechanisms including an antioxidant, α-glucosidase, and α-amylase inhibitory effect, up-regulation of adiponectin receptors, reduction of insulin resistance and glucose intestinal absorption, elevation of hepatic and muscular glycogen content, increase of insulin secretion, and phosphorylation of AMP-activated protein kinase [48]. This evidence concerns the gene INS and diabetes mellitus.