A positive association between CAD risk variants was demonstrated for ADTRP and melanoma inhibitory activity protein 3 (MIA3)/transport and Golgi organization protein 1 (TANGO1), whereby ADTRP up-regulates the expression of MIA3/TANGO1 through positive regulation of PIK3R3 and activation of AKT signaling [51]. This evidence concerns the gene ADTRP and coronary artery disorder.