Finally, two proteins were down-regulated in both groups of patients with migraine vs CTRL (Figure 2A), including apolipoprotein A-I (APOA1) and alpha-1-antitrypsin (A1AT), while two protein spots, identified as transthyretin (TTHY) and pepsin A-3 (PEPA3), were up-regulated in the same comparison. The gene discussed is PGA3; the disease is migraine disorder.