Finally, the expression intensity of APOA1 (Figure 4F) was confirmed to be strongly down-regulated (p < 0.001) in both migraineur groups compared to non-headache control women, and TTHY protein signals (Figure 4G) were up-regulated (p < 0.01) in the same comparisons, validating all previous results. The gene discussed is APOA1; the disease is Headache.