BAX and colorectal carcinoma: Metal NPs such as silver NPs (AgNPs) have been reported to cause downregulation of anti-apoptotic genes (Bcl-2 and Bcl-XL), and upregulation of pro-apoptotic genes (Bax, Bad and Bak) in HCT116 and CaCo2 CRC cells, and in HT-29 lung cancer cells [113,114,115,116,117].