Furthermore, lysine-based AGEs, such as CML, have shown to be involved in the biology of cancers by activating transcription factor NF-kB [62] and upregulating VEGF [63] to promote angiogenesis and induce DNA damage [64], leading to cancer progression. The gene discussed is NFKB1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.