In addition, APOA1 is capable of decreasing MMP-9 expression to reduce the invasive ability of cancer cells, and of inhibiting vascular endothelial growth factor (VEGF)-induced and basic fibroblast growth factor (bFGF)-induced vascular endothelial cell proliferation, migration, and tube formation, together preventing tumor angiogenesis [35]. The gene discussed is FGF2; the disease is cancer.