IGF2R and obesity due to melanocortin 4 receptor deficiency: The inhibition of miR-143-3p via the injection of anti-miR-143-3p in mice regulates the insulin-like growth factor 2 receptor (IGF2R) and prevents obesity-induced IR [153], and Aimin et al. reported that miR-34a–KO mice show HFD obesity-induced IR, systemic inflammation, and glucose intolerance [91].