AKT1 and cancer: In agreement with these reports and with the findings regarding circulating PE-modulated members of the C19MC cluster (some of which are cancer-related) [30], the signaling pathways modeling results showed that in addition to cancer-related KEGG pathways, Wnt, MAPK, PI3K-Akt, ErbB, GnRH, VEGF, B/T cell receptors, and ubiquitin-mediated proteolysis signaling pathways, were the most commonly modulated by the miRNAs altered in WWD-PE in our study.