MYCN and neuroblastoma: We selected SK-N-BE(2)-C cells, which are derived from a relapsed patient after chemotherapy [30] and recapitulate many aspects of advanced stage neuroblastoma, such as TP53 (tumor protein p53) mutation, MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog) amplification and relative treatment resistance towards chemotherapeutics [31].