Realtime RT-PCR analyses confirmed these findings for some selected genes (GABARAPL1, MAP1LC3a, WIPI1 and BNIP3L), as treatment with the both broad-spectrum HDAC inhibitors, vorinostat or panobinostat, resulted in upregulation of these genes in SK-N-BE(2)-C and IMR-32 neuroblastoma cells (Figure 2b,c). The gene discussed is MAP1LC3A; the disease is neuroblastoma.