TEAD-4 along with its coactivator, the Krüppel-like factor 5 (KLF5), a pro-survival TF, were among the nine genes reported to be overexpressed in high-grade ERα-negative tumors [123] and their high expression level was associated with poor prognosis and shorter survival in BC patients [122,124]. The gene discussed is ESR1; the disease is breast cancer.