Recently, research on patients and TNBC cell line-derived xenograft models, revealed that GR activation at distant metastatic sites, due to an increase in GC levels, promotes BC colonization and reduces the overall survival by upregulating the expression of ROR-1 kinase, a receptor tyrosine kinase-like orphan receptor-1, previously shown to be implicated in BC [13,117,118]. Here, RYK is linked to breast cancer.