Moreover, the highest-to-lowest tertiles of OPG conferred a significant risk with an odds ratio of 3.02 (1.13–8.07) for pathologically increased AS when the model was adjusted for IMT, ejection fraction, and NT-proBNP (first model), and IMT, hypertension, and the presence of clinically overt atherosclerotic manifestations (second model). The gene discussed is TNFRSF11B; the disease is hypertensive disorder.