Remarkably, Brca1/Trp53 double-inactivated tumors share common histopathological characteristics with human BRCA1 breast cancers, as they are also highly proliferative, estrogen receptor (ER)-negative carcinomas that push borders, express basal epithelial markers, and exhibit a high degree of genomic instability [155]. This evidence concerns the gene BRCA1 and carcinoma.