Interestingly, NTN4 shares the laminin domain with netrin-1 (NTN1), and there is evidence that NTN4 could exert its angiogenic roles via indirect interaction with the NTN1 putative receptors Unc-5 netrin receptor B (UNC5B) and Deleted in colorectal carcinoma (DCC) [9]. The gene discussed is UNC5B; the disease is colorectal carcinoma.